How did new biochemical pathways, which involve multiple enzymes working together in sequence, originate? Every pathway and nano-machine requires multiple protein/enzyme components to work. How did lucky accidents create even one of the components, let alone 10 or 20 or 30 at the same time, often in a necessary programmed sequence. Evolutionary biochemist Franklin Harold wrote, “we must concede that there are presently no detailed Darwinian accounts of the evolution of any biochemical or cellular system, only a variety of wishful speculations.”3 See: Design in living organisms (motors: ATP synthase)(includes animation).
Harold, Franklin M. (Prof. Emeritus Biochemistry, Colorado State University) The way of the cell: molecules, organisms and the order of life, Oxford University Press, New York, 2001, p. 205
Question 5 in CMI's '15 Questions for Evolutionists' flyer focuses on the silence from the evolutionary community regarding a naturalistic explanation for origin of complex biochemical pathways and nano-machines. This is another huge problem for evolution story (just like all the other questions in this series) requiring great faith on the part of those who believe evolution, in spite of the science against it.
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